2023 Early Hearing Detection & Intervention Conference

March 5-7, 2023 • Cincinnati, OH

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9/24/2018 | 11:45 AM - 12:15 PM | Results of a Targeted Screening Program for Congenital Cytomegalovirus Infection in Montreal, Quebec | Diamond Ballroom I

Results of a Targeted Screening Program for Congenital Cytomegalovirus Infection in Montreal, Quebec

Background: There remains considerable debate on the role of symptomatic, targeted vs. universal screening for cCMV infection. Here we report on a hospital-based targeted screening program for 1) Infants who failed their newborn hearing screen and 2) Infants of HIV infected mothers, and compare this to the prevalence among infants tested for CMV following clinical suspicion of a congenital infection. Methods: In November 2013, the “Programme québécois de dépistage de la surdité chez les nouveau-nés” (PQDNS) a provincially mandated hearing screening program was implemented at Centre Hospitalier Universitaire Sainte-Justine, a tertiary maternal-child health center in Montreal, Quebec, along with targeted CMV screening for all infants who failed their hearing test (excluding patients in the neonatal intensive care unit). Concurrently, beginning in April 2013, all infants of HIV exposed mothers were screened for cCMV infection within 48hrs of birth. Results: Out of 11 734 newborns screened for hearing through the PQDSN program between April 2014-March 2018, 536 failed their initial hearing screen, and 4 of these newborns tested positive for cCMV infection (0.75%). Out of a total of 130 HIV exposed newborns born during this period, 116 were screened for cCMV, and 3 (2.6%) confirmed positive. Overall, 455 newborns were identified by the attending pediatrician as having a risk factor for any congenital infection; of these, 22 (5.3%) tested positive for cCMV. Using these combined methods, a total of 0.24% of newborns enrolled in the PQDSN program tested positive for cCMV infection, Conclusions: The overall birth prevalence of cCMV was 0.75% among infants who failed their hearing screen, 2.6% among HIV exposed newborns, and 5.3% among infants with a clinical suspicion of a congenital infection. In the absence of universal screening, these results reinforce the importance of maintaining a high index of clinical suspicion for congenital infections.

To compare and contract the effectiveness of two different targeted screening methods for cCMV infection
To determine the effectiveness of symptom based screening
To understand the prevalence of cCMV infection among newborns in a tertiary care center in Quebec, Canada

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Presenters/Authors

Christian Renaud (), christian.renaud@umontreal.ca;
Christian Renaud is a pediatric infectious diseases specialist and medical microbiologist, who specialises in paediatric virology.